Field-scale evaluation of biosolids-derived organomineral fertilizers applied to winter wheat in England

Field-scale experiments in four crop seasons established the agronomic performance of biosolids-derived organomineral fertilizers (OMF) for winter wheat (Triticum aestivum L.) production in England. Two OMF formulations (OMF10 10:4:4 and OMF15 15:4:4) were compared with urea and biosolids granules (≈5:6:0.2) to determine crop responses and fertilizer effects on soil chemical properties. Fertilizers were applied at N rates between 0 and 250 kg ha–1 at regular increments of 50 kg ha–1 N. Average grain yields with OMF10 and OMF15 were higher than with biosolids granules, but lower than with urea (P < 0.05). The optimum N application rates, and corresponding grain yields, were 245 and 7900 kg ha–1 for biosolids, 257 and 9100 kg ha–1 for OMF10, 249 and 9500 kg ha–1 for OMF15, and 225 and 10350 kg ha–1 for urea, respectively. Differences in grain yield between fertilizer treatments were explained by differences in yield components, particularly number of grains and thousand-grain-weight. Grain-N recoveries were 31% for biosolids, ≈40% for OMF, and 52% for urea. Organomineral fertilizers-induced changes in soil extractable P and soil P Index were not significant. Thus, application of OMF replenished P offtake by the crop and therefore supported the choice of the proposed OMF formulations. By contrast, extractable P increased in biosolids and decreased in urea-treated soils, respectively. Heavy metals in soil were unaffected by fertilizer treatment and lower than permissible limit values. The use of OMF for winter wheat production appears to be a sustainable approach to recycling biosolids to land

Real-time, Software-Defined, GPU-Based Receiver Field Trial

We demonstrate stable real-time operation of a software-defined, GPU-based receiver over a metropolitan network. Massive parallelization is exploited for implementing direct-detection and coherent Kramers-Kronig detection in real time at 2 and 1 GBaud, respectively.Comment: Accepted for presentation at the European Conference on Optical Communications (ECOC) 202

Field Trial of a Flexible Real-time Software-defined GPU-based Optical Receiver

We introduce a flexible, software-defined real-time multi-modulation format receiver implemented on an off-the-shelf general-purpose graphics processing unit (GPU). The flexible receiver is able to process 2 GBaud 2-, 4-, 8-, and 16-ary pulse-amplitude modulation (PAM) signals as well as 1 GBaud 4-, 16- and 64-ary quadrature amplitude modulation (QAM) signals, with the latter detected using a Kramers-Kronig (KK) coherent receiver. Experimental performance evaluation is shown for back-to-back. In addition, by using the JGN high speed R&D network testbed, performance is evaluated after transmission over 91 km field-deployed optical fiber and reconfigurable optical add-drop multiplexers (ROADMs).Comment: Accepted for publication at Journal of Lightwave Technology, already available via JLT Early Access, see supplied DOI. This v2 version of the article is improved w.r.t. v1 after JLT peer-review. This article is a longer journal version of the conference paper: S.P. van der Heide, et al., Real-time, Software-Defined, GPU-Based Receiver Field Trial, ECOC 2020 paper We1E5, also via arXiv:2010.1433

Real-time transmission of geometrically-shaped signals using a software-defined GPU-based optical receiver

A software-defined optical receiver is implemented on an off-the-shelf commercial graphics processing unit (GPU). The receiver provides real-time signal processing functionality to process 1 GBaud minimum phase (MP) 4-, 8-, 16-, 32-, 64-, 128-ary quadrature amplitude modulation (QAM) as well as geometrically shaped (GS) 8- and 128-QAM signals using Kramers-Kronig (KK) coherent detection. Experimental validation of this receiver over a 91 km field-deployed optical fiber link between two Tokyo locations is shown with detailed optical signal-to-noise ratio (OSNR) investigations. A net data rate of 5 Gbps using 64-QAM is demonstrated.</p

Strong coupling effects in hybrid plexitonic systems

Trabajo presentado a la 3rd International Conference on Applications of Optics and Photonics, celebrado en Faro (Portugal) del 8 al 12 de mayo de 2017.We investigated the interactions between localized plasmons in gold nanorods and excitons in J-aggregates and were able to track an anticrossing behavior of the hybridized modes both in the extinction and in the photoluminescence spectra of this hybrid system. We identified the nonlinear optical behavior of this system by transient absorption spectroscopy. Finally using magnetic circular dichroism spectroscopy we showed that nonmagnetic organic molecules exhibit magneto-optical response due to binding to a plasmonic nanoparticles. In our experiments we also studied the effect of detuning as well as the effect of off- and on resonance excitation on the hybrid states.We acknowledge financial support from Project Fis2016.80174-P (PLASMOQUANTA) from MINECO (Ministerio de Economía y Competitividad). L.L.-M. acknowledges funding from the European Research Council (ERC Advanced Grant 267867, Plasmaquo). This study was supported by the Ministry of Education and Science of the Russian Federation, grant no. 14.Y26.31.0011.Peer Reviewe

Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures

Using a new consensus-based image-processing approach together with principal component analysis, the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state have been analysed. These studies revealed concerted motions involving the receptor-binding domain (RBD), N-terminal domain, and subdomains 1 and 2 around the previously characterized 1-RBD-up state, which have been modeled as elastic deformations. It is shown that in this data set there are not well defined, stable spike conformations, but virtually a continuum of states. An ensemble map was obtained with minimum bias, from which the extremes of the change along the direction of maximal variance were modeled by flexible fitting. The results provide a warning of the potential image-processing classification instability of these complicated data sets, which has a direct impact on the interpretability of the results.The authors would like to acknowledge financial support from CSIC (PIE/COVID-19 No. 202020E079), the Comunidad de Madrid through grant CAM (S2017/BMD-3817), the Spanish Ministry of Science and Innovation through projects SEV 2017-0712, FPU-2015/264 and PID2019-104757RB-I00/AEI/ FEDER, the Instituto de Salud Carlos III [PT17/0009/0010 (ISCIII-SGEFI/ERDF)], and the European Union and Horizon 2020 through grants INSTRUCT–ULTRA (INFRADEV-03-2016-2017, Proposal 731005), EOSC Life (INFRAEOSC-04-2018, Proposal 824087), HighResCells (ERC-2018-SyG, Proposal 810057), IMpaCT (WIDESPREAD- 03-2018, Proposal 857203), CORBEL (INFRADEV-1-2014-1, Proposal 654248) and EOSC–Synergy (EINFRA-EOSC-5, Proposal 857647). HDT and BF were supported by NIH grant GM125769 and JSM was supported by NIH grant R01-AI12752

Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries

IMPORTANCE: Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). OBJECTIVES: To evaluate intensive care unit (ICU) incidence and outcome of ARDS and to assess clinician recognition, ventilation management, and use of adjuncts-for example prone positioning-in routine clinical practice for patients fulfilling the ARDS Berlin Definition. DESIGN, SETTING, AND PARTICIPANTS:The Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients undergoing invasive or noninvasive ventilation, conducted during 4 consecutive weeks in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across 5 continents. EXPOSURES:Acute respiratory distress syndrome. MAIN OUTCOMES AND MEASURES: The primary outcome was ICU incidence of ARDS. Secondary outcomes included assessment of clinician recognition of ARDS, the application of ventilatory management, the use of adjunctive interventions in routine clinical practice, and clinical outcomes from ARDS. RESULTS: Of 29,144 patients admitted to participating ICUs, 3022 (10.4%) fulfilled ARDS criteria. Of these, 2377 patients developed ARDS in the first 48 hours and whose respiratory failure was managed with invasive mechanical ventilation. The period prevalence of mild ARDS was 30.0% (95% CI, 28.2%-31.9%); of moderate ARDS, 46.6% (95% CI, 44.5%-48.6%); and of severe ARDS, 23.4% (95% CI, 21.7%-25.2%). ARDS represented 0.42 cases per ICU bed over 4 weeks and represented 10.4% (95% CI, 10.0%-10.7%) of ICU admissions and 23.4% of patients requiring mechanical ventilation. Clinical recognition of ARDS ranged from 51.3% (95% CI, 47.5%-55.0%) in mild to 78.5% (95% CI, 74.8%-81.8%) in severe ARDS. Less than two-thirds of patients with ARDS received a tidal volume 8 of mL/kg or less of predicted body weight. Plateau pressure was measured in 40.1% (95% CI, 38.2-42.1), whereas 82.6% (95% CI, 81.0%-84.1%) received a positive end-expository pressure (PEEP) of less than 12 cm H2O. Prone positioning was used in 16.3% (95% CI, 13.7%-19.2%) of patients with severe ARDS. Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning. Hospital mortality was 34.9% (95% CI, 31.4%-38.5%) for those with mild, 40.3% (95% CI, 37.4%-43.3%) for those with moderate, and 46.1% (95% CI, 41.9%-50.4%) for those with severe ARDS. CONCLUSIONS AND RELEVANCE: Among ICUs in 50 countries, the period prevalence of ARDS was 10.4% of ICU admissions. This syndrome appeared to be underrecognized and undertreated and associated with a high mortality rate. These findings indicate the potential for improvement in the management of patients with ARDS